… penetrance, and is most often caused by variants in genes … be included in clinical follow-up
programs with possibilities … and sensitivity of predictive genetic testing in HCM. Future …

… Genetic testing identifies a P/LP variant in ≈30% to 40… studies including older carriers
reported higher penetrance rates. This emphasizes the need for studies with extended follow-up of …

… is the low penetrance of HCM during childhood. Previous … +SV3 is effective in predicting a
potential diagnosis of HCM in the 1st … their concerns and develop requirements for follow-up. …

… , due to its incomplete penetrance and variable expressivity. The … During the 12-year study
period, the estimated annual … first year of life during the follow-up period. Furthermore, for each …

… with worse clinical outcomes and increased penetrance in at-… , the follow-up of paediatric
cardiac disease, and for research … This is a 12-year-old girl MRI depicting severe DCM …

… genetic testing and demonstrate how genetic testing results can help patients and their families.
Knowledge that a MolDx can impact clinical … less comfortable utilizing genetic testing, to …

… the child from regular clinical follow-up, … clinical features, such as ECG abnormalities, are
predictive of subsequent phenotype development, age at screening is not, and the penetrance …

… to help clinicians counsel families on predictive genetic testing … Incomplete penetrance and
variable expression is the norm … HCM features, with closer follow up during typical periods of …

… Follow-up serial imaging with contrast CMR about every 3 to 5 … with variable penetrance,
associated with variants in genes … Genetic testing also identifies clinically silent genetically …

… at HCM diagnosis and sarcomeric mutations are predictive of … serial clinical evaluations
because of age-related penetrance (15). … Larger scale studies with longer follow-up durations are …